anyone who plays at a certain level of competency in pot limit omaha can tell you that their is a vast difference between playing in a game with sharp, tough players, and playing against a bunch of jokers who have only played a couple of times. for these loose games i would not reccomend the playing style i am about to discuss. this is because novice omaha players often strongly over estimate the value of their hands. tihs makes so that weakness is hard to exploit when their more than willing to get their money in with any two cards. 
    now i am not saying dont play in loose PLO games! play in them as much as possible. what i am saying is the basic rule that most experienced players learn. dont try and play a finesse game against those who cant understand finesse. the beauty of these games is that your going to get paid off far more often than in a solid PLO game with tight players.    
        in a tight PLO game with  decent players, exploiting weakness is the name of the game. the semi-bluff becomes much more important. you need to be prepared to forcefully bet your hands and be willing to get it in with huge draws when you either: A. know your opponents are going to fold. or B.  are willing to gamble on a large enough draw.     
    example:   you are two off the gun in a 1-2 PLO game and are currently 9 handed. it is folded to you and you have 4H 5H AD KC. you limp and everyone folds to the cutoff who pots. the button calls and the blinds and everyone else fold  to you. yuou call and   the flop comes:   
      QH 10H 5D . in this situation the obvious decision is to srongly bet this pot, but you dont want to get all your money in on flop. tjhis is because if you continue to get potted and repotted, sonmeone is trying to find out if a small set is good most likely. smooth calling to the turn will put the fear of god into them. on the turn is when you need to excercise your power and steal. unless the board pairs. nearly any card wins you this pot against smart players. even cards that dont help you. a blank on the turn should be your sign to pot immediately. probably 80% of the  time you will take down the pot here with only a draw. a small set will be sure he is beat. the key to winning in the long run at tight omaha is utilizing theses type of plays. you have to go after the orphan pots